You will be able to unlock this during episode 3 and the achievement popped for me whilst I had created the following:
Alcohol + Grass = Absinthe
Alcohol + Pirate = Rum
Alcohol + Worm = Tequila
Vodka + Coffee = B52
Vodka + Milk = White Russian
This was after having created all the items prior for the previous episodes such as Beer, Milk, Alcohol and Vodka
This achievement is easy, if your struggling to find reactions click the link below, it will take you to a wiki showing you every combination needed to reach level two. Do all of these and the achievement will pop.