To unlock space 54 you need to have gotten 5 golden fingers on previous levels. For that I recommend playing the Astral Stair level for that. I explained better that on my solution for the other achievement.
After you've entered the level and if you've unlocked Randomazzo, choose the VIII card (the one that looks like a tree with a green background). If you've unlocked it. It will attract the Empty tombs and the candelabradors, then choose the following weapons/passives below:
Weapons: Water - Bible - Axe - Knife. The other 2 weapons are on your choice.
Passive: Attractorb (Evolves water) - Spellbinder (Evolves bible) - Candelabrador (evolves Axe) - Bracer (Evolves Knife) - Empty Tomb - Hollow Heart (Important, since you need as much HP points as you can).
If you have the chance try to evolve first the water and bible and then the axe and the knife.
Once the 20 minute mark has been passed you’ll beat the level and this achievement will pop